Fertility

Nutritional Foundation for Healthy Fertility with MAXMIL®

The success of pregnancy and the health of future generations are largely determined from the preconception phase. Infertility has become a global issue, affecting around 15% of couples of reproductive age. In 2021, Indonesia ranked second in infertility prevalence among Asia-Pacific countries.

The causes of infertility are highly complex, ranging from lifestyle factors (stress, smoking, obesity), environmental exposures (pollutants, pesticides, heavy metals), to underlying health problems such as PCOS, endometriosis, and hormonal imbalances. Assisted Reproductive Technology (ART), including In Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI), offers hope, but remains limited by high costs, invasive procedures, variable success rates, and its inability to address the root causes—namely, the quality of gametes.

Micronutrients: The Foundation of Fertility

Micronutrients are now recognized as critical determinants in cellular processes that support gamete quality (sperm and oocytes) and successful conception. Their roles include:

  1. Supporting healthy gametogenesis through DNA synthesis, meiosis, and maturation of sperm and oocytes.

  2. Providing cellular protection by enhancing antioxidant defenses against oxidative stress that damages gamete DNA.

  3. Regulating hormones, as certain vitamins and minerals influence the production of testosterone, estrogen, and thyroid hormones.

  4. Ensuring healthy gene expression through epigenetic regulation and DNA methylation from the earliest stages of embryogenesis.

Micronutrient deficiencies have been proven to reduce sperm and oocyte quality, impair ovulation, increase DNA fragmentation, and lower the success rate of both natural conception and ART. Acting as enzymatic cofactors, micronutrients optimize metabolic pathways essential for high-quality gamete production, especially during the periconceptional phase.

MAXMIL®: Complete Nutritional Support for Fertility

MAXMIL® is formulated with 18 essential micronutrients that work synergistically to support fertility in both men and women:

  • 5-MTHF (Active Folate): Supports DNA synthesis, gamete quality, and lowers miscarriage risk.

  • Vitamin K2 (MenaQ7®), Coral Calcium, Vitamin D3, and Magnesium: Work together to prevent calcium paradox and ensure calcium is directed to bones and fetal organs.

  • DHA (Omega-3): Enhances sperm and oocyte membrane fluidity, improving embryo quality.

  • Vitamins E & C: Powerful antioxidants protecting gamete DNA from oxidative stress.

  • Vitamin D3: Improves testosterone levels, sperm motility, oocyte quality, and embryo implantation.

  • Zinc & Magnesium: Key cofactors for spermatogenesis, meiosis, chromatin integrity, and germ cell energy.

  • Vitamin A (Beta-Carotene): Supports germ cell maturation and improves oocyte and embryo quality.

  • B-Complex Vitamins (B1, B2, B6, B12): Essential for energy metabolism, DNA methylation, sperm quality, and oocyte maturation.

  • Biotin & Nicotinamide (B3): Maintain mitochondrial energy metabolism in gametes and genomic stability.

  • Iron & Iodine: Support DNA synthesis, cellular energy, thyroid function, ovulation, and follicular growth.

The Role of Folate and 5-MTHF (Active Folate) in MAXMIL®

Folate is crucial for DNA synthesis and epigenetic methylation, both essential for gamete formation and embryo development. However, regular folic acid requires conversion by the methylenetetrahydrofolate reductase (MTHFR) enzyme. In individuals with MTHFR polymorphisms (C677T/A1298C)—affecting up to 42% of the Southeast Asian population—the efficiency of this conversion can be reduced by up to 70%.

The consequences include:

  • Elevated homocysteine levels → reduced gamete quality and higher miscarriage risk.

  • Accumulation of unmetabolized folic acid (UMFA) → linked to fertility and pregnancy complications.

5-MTHF (Active Folate) in MAXMIL® provides a direct solution:

  • Already in its active form, ready to be used by the body without reliance on MTHFR.

  • More efficient in raising blood folate levels and reducing homocysteine.

  • Eliminates the risk of UMFA buildup.

Clinical studies show that 5-MTHF supplementation in IVF women improves oocyte and embryo quality, as well as pregnancy rates. In a study of 33 couples with recurrent miscarriages, 5-MTHF therapy for 4 months led to 26 successful pregnancies (86.7%), both naturally and via ART.

Conclusion

A new paradigm in fertility highlights the importance of nutritional optimization from the preconception stage. MAXMIL® provides a comprehensive formulation that:

  1. Improves sperm and oocyte quality

  2. Maintains hormonal balance

  3. Protects DNA and supports epigenetic regulation

  4. Creates the best environment for successful pregnancy

The inclusion of 5-MTHF (Active Folate) in MAXMIL® is a specific solution for couples with folate deficiency or MTHFR polymorphisms, clinically proven to enhance conception and healthy pregnancy outcomes. With this approach, fertility is not solely dependent on invasive medical technologies, but can be nutritionally programmed to build the foundation of a healthier generation.


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